human HNRNPAB shRNA silencing AAV

Name
AAV-h-HNRNPAB-shRNA

Cat No
shAAV-211357

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HNRNPAB.

shAAV-211357

AAV-h-HNRNPAB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ABBP1; HNRPAB

Description (Vector)

HNRNPAB belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

3182

Gene Name (Vector)

heterogeneous nuclear ribonucleoprotein A/B

Gene Symbol

HNRNPAB

HGNC ID

HGNC:5034

ORF Size (aa)

999

ORF Size (bp)

999 bp

RefSeq ID

NM_004499

RefSeq Synonyms

NM_031266, NM_004499, BC036708, BC009359, BC004561, BC002625, BC001616,

Species

human

UniGene ID

Hs.715055

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.