human HMGCL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HMGCL.
shAAV-211281
AAV-h-HMGCL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HMGCL (3-hydroxymethyl-3-methylglutaryl-CoA lyase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HL
Description (Vector)
HMGCL belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
3155
Gene Name (Vector)
3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Symbol
HMGCL
HGNC ID
HGNC:5005
ORF Size (aa)
978
ORF Size (bp)
978 bp
RefSeq ID
NM_000191
RefSeq Synonyms
NM_001166059, NM_000191, BC010570,
Species
human
UniGene ID
Hs.533444
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.