human HLA-E shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HLA-E.
shAAV-211235
AAV-h-HLA-E-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HLA-E (major histocompatibility complex, class I, E). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HLA-6.2; QA1
Description (Vector)
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
Gene ID
3133
Gene Name (Vector)
major histocompatibility complex, class I, E
Gene Symbol
HLA-E
HGNC ID
HGNC:4962
ORF Size (aa)
1077
ORF Size (bp)
1077 bp
RefSeq ID
NM_005516
RefSeq Synonyms
NM_005516, BC040479, BC002578,
Species
human
UniGene ID
Hs.650174
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.