human HBS1L shRNA silencing AAV

Name
AAV-h-HBS1L-shRNA

Cat No
shAAV-210830

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HBS1L.

shAAV-210830

AAV-h-HBS1L-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HBS1L (HBS1 like translational GTPase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EF-1a; eRF3 family member; eRF3c; ERF3-similar protein; ERFS; HBS1; HBS1-like protein; Hsp70 subfamily B suppressor 1-like protein; HSPC276

Description (eCommerce)

HBS1-like protein (HBS1L) is a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscl [taken from NCBI Entrez Gene (Gene ID: 10767)].

Description (Vector)

HBS1L encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Gene ID

10767

Gene Name (eCommerce)

HBS1 like translational GTPase

Gene Name (Vector)

HBS1 like translational GTPase

Gene Symbol

HBS1L

HGNC ID

HGNC:4834

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2055

ORF Size (bp)

2055 bp

Protein Name (eCommerce)

HBS1-like protein

RefSeq ID

NM_006620

RefSeq Synonyms

NM_006620, NM_001145207, NM_001145158, BC040849, BC001465,

Research Areas

Signal Transduction,Translational Control

Research Areas (Faceted)

cell_biology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.378532

UniProt ID (eCommerce)

Q9Y450

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.