human GZMB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GZMB.
shAAV-210718
AAV-h-GZMB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GZMB (granzyme B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C11; cathepsin G-like 1; CCPI; CGL1; CGL-1; CSPB; CSP-B; CTLA1; CTLA-1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; fragmentin 2; Fragmentin-2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme-2; HLP; human lymphocyte protein; Lymphocyte protease; SECT; T-cell serine protease 1-3E
Description (eCommerce)
Granzyme B is a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing [taken from NCBI Entrez Gene (Gene ID: 3002)]
Description (Vector)
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Gene ID
3002
Gene Name (eCommerce)
granzyme B
Gene Name (Vector)
granzyme B
Gene Symbol
GZMB
HGNC ID
HGNC:4709
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
744
ORF Size (bp)
744 bp
Protein Name (eCommerce)
Granzyme B
RefSeq ID
NM_004131
RefSeq Synonyms
NM_004131, NM_001346011, BC030195,
Research Areas
Apoptosis,Cancer,Immunology,Interleukin Signaling,Neurobiology,Notch Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Granzyme B is a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing [taken from NCBI Entrez Gene (Gene ID: 3002)]
UniGene ID
Hs.1051
UniProt ID (eCommerce)
P10144
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.