human GUCY1B3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GUCY1B3.
shAAV-210689
AAV-h-GUCY1B3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GUCY1B3 (guanylate cyclase 1 soluble subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1
Description (Vector)
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 (PubMed 9742212)).(supplied by OMIM, Mar 2008)
Gene ID
2983
Gene Name (Vector)
guanylate cyclase 1 soluble subunit beta
Gene Symbol
GUCY1B3
HGNC ID
HGNC:4687
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
RefSeq ID
NM_000857
RefSeq Synonyms
NM_001291955, NM_001291954, NM_001291953, NM_001291952, NM_001291951, NM_000857, BC047620,
Species
human
UniGene ID
Hs.77890
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.