human GTSE1 shRNA silencing AAV

Name
AAV-h-GTSE1-shRNA

Cat No
shAAV-210668

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GTSE1.

shAAV-210668

AAV-h-GTSE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GTSE1 (G2 and S-phase expressed 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B99; G2 and S phase-expressed protein 1; G-2 and S-phase expressed 1; GTSE-1; protein B99 homolog

Description (eCommerce)

GTSE1 (G-2 and S-phase expressed 1) is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, GTSE1 accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis [taken from NCBI Entrez Gene (GeneID: 51512)].

Description (Vector)

GTSE1 is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.

Gene ID

51512

Gene Name (eCommerce)

G2 and S-phase expressed 1

Gene Name (Vector)

G2 and S-phase expressed 1

Gene Symbol

GTSE1

HGNC ID

HGNC:13698

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2163

ORF Size (bp)

2163 bp

Protein Name (eCommerce)

G2 and S phase-expressed protein 1

RefSeq ID

NM_016426

RefSeq Synonyms

NM_016426, BC075828, BC006325,

Research Areas

Cell Cycle,Cytoskeleton,DNA Damage/Repair,p53 Signaling,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction

Species

human

Target Sentence

GTSE1 (G-2 and S-phase expressed 1) is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, GTSE1 accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis [taken from NCBI Entrez Gene (GeneID: 51512)].

UniGene ID

Hs.386189

UniProt ID (eCommerce)

Q9NYZ3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.