human GTF2I shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GTF2I.
shAAV-210649
AAV-h-GTF2I-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GTF2I (general transcription factor IIi). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAP135; BAP-135; Bruton tyrosine kinase-associated protein 135; BTKAP1; BTK-associated protein 135; BTK-associated protein, 135kD; DIWS; general transcription factor II-I; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Description (eCommerce)
GTF2I/TFII-I is a multi-functional transcription factor that interacts with the basal transcription machinery and links upstream cellular signals to responsive activator complexes that associate with the C-FOS promoter and other response elements. Haploinsufficiency of GTF2I/TFII-I results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
Description (Vector)
GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.
Gene ID
2969
Gene Name (eCommerce)
general transcription factor IIi
Gene Name (Vector)
general transcription factor IIi
Gene Symbol
GTF2I
HGNC ID
HGNC:4659
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2931
ORF Size (bp)
2931 bp
Protein Name (eCommerce)
General transcription factor II-I
RefSeq ID
NM_001518
RefSeq Synonyms
NM_033001, NM_033000, NM_032999, NM_001518, NM_001280800, NM_001163636, BC099907, BC070484,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Host-Virus Interactions,Immunology,Neurobiology,Signal Transduction,TNF Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
GTF2I/TFII-I is a multi-functional transcription factor that interacts with the basal transcription machinery and links upstream cellular signals to responsive activator complexes that associate with the C-FOS promoter and other response elements. Haploinsufficiency of GTF2I/TFII-I results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
UniGene ID
Hs.647041
UniProt ID (eCommerce)
P78347
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.