human GTF2A1 shRNA silencing AAV

Name 
AAV-h-GTF2A1-shRNA
Cat No 
shAAV-210628
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GTF2A1.

shAAV-210628
AAV-h-GTF2A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GTF2A1 (general transcription factor IIA subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
general transcription factor IIA 1; General transcription factor IIA subunit 1; general transcription factor IIA, 1, 19/37kDa; glucose regulated protein, 58kD pseudogene; TF2A1; TFIIA; TFIIA alpha, p55; TFIIA alpha/beta subunits; TFIIA-42; TFIIAL; transcription initiation factor IIA subunit 1; transcription initiation factor TFIIA 42 kDa subunit
Description (eCommerce)
GTF2A1/TFIIA (general transcription factor IIA subunit 1) is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. gTF2A1/TFIIA in a complex with TBP mediates transcriptional activity [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/P52655].
Description (Vector)
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 (PubMed 8224848)). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.(supplied by OMIM, Jul 2010)
Gene ID
2957
Gene Name (eCommerce)
general transcription factor IIA subunit 1
Gene Name (Vector)
general transcription factor IIA subunit 1
Gene Symbol
GTF2A1
HGNC ID
HGNC:4646
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1131
ORF Size (bp)
1131 bp
Protein Name (eCommerce)
Transcription initiation factor IIA subunit 1
RefSeq ID
NM_015859
RefSeq Synonyms
NM_201595, NM_015859, NM_001278940, BC107156, BC107155,
Research Areas
Cancer,Chromatin Remodeling,Gene Expression,Host-Virus Interactions,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
GTF2A1/TFIIA (general transcription factor IIA subunit 1) is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. gTF2A1/TFIIA in a complex with TBP mediates transcriptional activity [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/P52655].
UniGene ID
Hs.593630
UniProt ID (eCommerce)
P52655

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.