human GRIN2A shRNA silencing AAV

Name
AAV-h-GRIN2A-shRNA

Cat No
shAAV-210522

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GRIN2A.

shAAV-210522

AAV-h-GRIN2A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A

Description (Vector)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

2903

Gene Name (Vector)

glutamate ionotropic receptor NMDA type subunit 2A

Gene Symbol

GRIN2A

HGNC ID

HGNC:4585

ORF Size (aa)

3846

ORF Size (bp)

3846 bp

RefSeq ID

NM_000833

RefSeq Synonyms

NM_001134408, NM_001134407, NM_000833, BC143273, BC117131,

Species

human

UniGene ID

Hs.411472

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.