human GPS2 shRNA silencing AAV

Name
AAV-h-GPS2-shRNA

Cat No
shAAV-210440

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GPS2.

shAAV-210440

AAV-h-GPS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPS2 (G protein pathway suppressor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AMF-1

Description (Vector)

GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Gene ID

2874

Gene Name (Vector)

G protein pathway suppressor 2

Gene Symbol

GPS2

HGNC ID

HGNC:4550

ORF Size (aa)

984

ORF Size (bp)

984 bp

RefSeq ID

NM_004489

RefSeq Synonyms

NM_004489, BC107738, BC103903, BC103901, BC013652,

Species

human

UniGene ID

Hs.438219

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.