human GP5 shRNA silencing AAV

Name
AAV-h-GP5-shRNA

Cat No
shAAV-210190

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GP5.

shAAV-210190

AAV-h-GP5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GP5 (glycoprotein V platelet). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD42d; GPV

Description (Vector)

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 (PubMed 9616133)).(supplied by OMIM, Nov 2010)

Gene ID

2814

Gene Name (Vector)

glycoprotein V platelet

Gene Symbol

GP5

HGNC ID

HGNC:4443

ORF Size (aa)

1680

ORF Size (bp)

1680 bp

RefSeq ID

NM_004488

RefSeq Synonyms

NM_004488, BC152810,

Species

human

UniGene ID

Hs.73734

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.