human GLI1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GLI1.
shAAV-209965
AAV-h-GLI1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GLI1 (GLI family zinc finger 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLI; GLI-Kruppel family member GLI1; Glioma-associated oncogene; glioma-associated oncogene 1; glioma-associated oncogene homolog 1 (zinc finger protein); oncogene GLI; PAPA8; zinc finger protein GLI1
Description (eCommerce)
GLI1, a member of the Kruppel family of zinc finger proteins, is a transcription factor activated by the sonic hedgehog signal transduction cascade that regulates stem cell proliferation. The activity and nuclear localization of GLI1 is negatively regulated by p53 in an inhibitory loop. [taken from NCBI Entrez Gene (Gene ID: 2735)].
Description (Vector)
GLI1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
2735
Gene Name (eCommerce)
GLI family zinc finger 1
Gene Name (Vector)
GLI family zinc finger 1
Gene Symbol
GLI1
HGNC ID
HGNC:4317
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3321
ORF Size (bp)
3321 bp
Protein Name (eCommerce)
Zinc finger protein GLI1
RefSeq ID
NM_005269
RefSeq Synonyms
NM_005269, NM_001167609, NM_001160045, BC013000,
Research Areas
Cancer,Hedgehog Signaling,Neurobiology,Neurodevelopment,Signal Transduction,Spermatogenesis,Transcription Factor / Regulator,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
GLI1, a member of the Kruppel family of zinc finger proteins, is a transcription factor activated by the sonic hedgehog signal transduction cascade that regulates stem cell proliferation. The activity and nuclear localization of GLI1 is negatively regulated by p53 in an inhibitory loop. [taken from NCBI Entrez Gene (Gene ID: 2735)].
UniGene ID
Hs.632702
UniProt ID (eCommerce)
P08151
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.