human GIT2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GIT2.
shAAV-209910
AAV-h-GIT2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GIT2 (GIT ArfGAP 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARF GAP GIT2; ARF GTPase-activating protein GIT2; CAT2; CAT-2; cool-associated, tyrosine phosphorylated protein 2; cool-interacting tyrosine-phosphorylated protein 2; G protein-coupled receptor kinase interacting ArfGAP 2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; Paxillin kinase linker; PKL
Description (eCommerce)
G-protein-coupled receptor kinase interactor 1 (GIT1) and G-protein-coupled receptor kinase interactor 2 (GIT2) are GTPase-activating proteins for ADP-ribosylation (Arf) GTPases. GIT1 and GIT2 regulate Arf activity and the sequestration of activated G protein-coupled receptors from the surface of the cell. These activities have effects on multiple cellular processes such as cell migration, T-cell activation, and centrosome dynamics. Both GIT proteins also serve as scaffolds to link signaling molecules.
Description (Vector)
GIT2 encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. GIT2 has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Gene ID
9815
Gene Name (eCommerce)
GIT ArfGAP 2
Gene Name (Vector)
GIT ArfGAP 2
Gene Symbol
GIT2
HGNC ID
HGNC:4273
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1416
ORF Size (bp)
1416 bp
Protein Name (eCommerce)
ARF GTPase-activating protein GIT2
RefSeq ID
NM_057169
RefSeq Synonyms
NM_139201, NM_057170, NM_057169, NM_014776, NM_001330154, NM_001330153, NM_001135214, NM_001135213, BC014223, BC001379,
Research Areas
EGFR Signaling,Immunology,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling,Zinc-finger
Research Areas (Faceted)
signal_transduction,immunology,neurobiology,developmental_biology,signal_transduction,immunology,cell_biology
Species
human
Target Sentence
G-protein-coupled receptor kinase interactor 1 (GIT1) and G-protein-coupled receptor kinase interactor 2 (GIT2) are GTPase-activating proteins for ADP-ribosylation (Arf) GTPases. GIT1 and GIT2 regulate Arf activity and the sequestration of activated G protein-coupled receptors from the surface of the cell. These activities have effects on multiple cellular processes such as cell migration, T-cell activation, and centrosome dynamics. Both GIT proteins also serve as scaffolds to link signaling molecules.
UniGene ID
Hs.434996
UniProt ID (eCommerce)
Q14161
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.