human GCLM shRNA silencing AAV

Name
AAV-h-GCLM-shRNA

Cat No
shAAV-209746

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GCLM.

shAAV-209746

AAV-h-GCLM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GCLM (glutamate-cysteine ligase modifier subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GLCLR

Description (Vector)

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene ID

2730

Gene Name (Vector)

glutamate-cysteine ligase modifier subunit

Gene Symbol

GCLM

HGNC ID

HGNC:4312

ORF Size (aa)

825

ORF Size (bp)

825 bp

RefSeq ID

NM_002061

RefSeq Synonyms

NM_002061, NM_001308253, BC041809,

Species

human

UniGene ID

Hs.315562

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.