human GCA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GCA.
shAAV-209728
AAV-h-GCA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GCA (grancalcin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GCL
Description (Vector)
GCA product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
Gene ID
25801
Gene Name (Vector)
grancalcin
Gene Symbol
GCA
HGNC ID
HGNC:15990
ORF Size (aa)
654
ORF Size (bp)
654 bp
RefSeq ID
NM_012198
RefSeq Synonyms
NM_012198, NM_001330271, NM_001330270, NM_001330268, NM_001330267, NM_001330266, NM_001330265, BC005214,
Species
human
UniGene ID
Hs.377894
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.