human GALNT4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GALNT4.
shAAV-209597
AAV-h-GALNT4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GALNAC-T4; GALNACT4
Description (Vector)
GALNT4 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist.
Gene ID
8693
Gene Name (Vector)
polypeptide N-acetylgalactosaminyltransferase 4
Gene Symbol
GALNT4
HGNC ID
HGNC:4126
ORF Size (aa)
1737
ORF Size (bp)
1737 bp
RefSeq ID
NM_003774
RefSeq Synonyms
NM_003774, BC036390,
Species
human
UniGene ID
Hs.713979
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.