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human GABRA4 shRNA silencing AAV

Name 
AAV-h-GABRA4-shRNA
Cat No 
shAAV-209509
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GABRA4.

shAAV-209509
AAV-h-GABRA4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GABRA4 (gamma-aminobutyric acid type A receptor alpha4 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GABA(A) receptor subunit alpha-4; GABA(A) receptor, alpha 4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid A receptor alpha 4; gamma-aminobutyric acid receptor subunit alpha-4
Description (eCommerce)
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. GABRA4 is the alpha-4 subunit, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1) [taken from NCBI Entrez Gene (Gene ID: 2557)].
Description (Vector)
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
Gene ID
2557
Gene Name (eCommerce)
gamma-aminobutyric acid type A receptor alpha4 subunit
Gene Name (Vector)
gamma-aminobutyric acid type A receptor alpha4 subunit
Gene Symbol
GABRA4
HGNC ID
HGNC:4078
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1665
ORF Size (bp)
1665 bp
Protein Name (eCommerce)
Gamma-aminobutyric acid receptor subunit alpha-4
RefSeq ID
NM_000809
RefSeq Synonyms
NM_001204267, NM_001204266, NM_000809, BC035055,
Research Areas
Cardiology,Cardiovascular,Neurobiology,Neurodevelopment,Signal Transduction,Synapse
Research Areas (Faceted)
cardiovascular,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. GABRA4 is the alpha-4 subunit, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1) [taken from NCBI Entrez Gene (Gene ID: 2557)].
UniGene ID
Hs.248112
UniProt ID (eCommerce)
P48169

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.