human GABRA1 shRNA silencing AAV

Name
AAV-h-GABRA1-shRNA

Cat No
shAAV-209506

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GABRA1.

shAAV-209506

AAV-h-GABRA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GABRA1 (gamma-aminobutyric acid type A receptor alpha1 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ECA4; EIEE19; EJM; EJM5

Description (Vector)

GABRA1 encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.

Gene ID

2554

Gene Name (Vector)

gamma-aminobutyric acid type A receptor alpha1 subunit

Gene Symbol

GABRA1

HGNC ID

HGNC:4075

ORF Size (aa)

1371

ORF Size (bp)

1371 bp

RefSeq ID

NM_000806

RefSeq Synonyms

NM_001127648, NM_001127647, NM_001127646, NM_001127645, NM_001127644, NM_001127643, NM_000806, BC030696,

Species

human

UniGene ID

Hs.175934

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.