human G6PC shRNA silencing AAV

Name
AAV-h-G6PC-shRNA

Cat No
shAAV-209478

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human G6PC.

shAAV-209478

AAV-h-G6PC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human G6PC (glucose-6-phosphatase catalytic subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

G6Pase; G6PC1; G6PT; GSD1; GSD1a

Description (Vector)

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.

Gene ID

2538

Gene Name (Vector)

glucose-6-phosphatase catalytic subunit

Gene Symbol

G6PC

HGNC ID

HGNC:4056

ORF Size (aa)

1074

ORF Size (bp)

1074 bp

RefSeq ID

NM_000151

RefSeq Synonyms

NM_001270397, NM_000151, BC136369, BC130478,

Species

human

UniGene ID

Hs.212293

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.