human FZD4 shRNA silencing AAV

Name
AAV-h-FZD4-shRNA

Cat No
shAAV-209464

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FZD4.

shAAV-209464

AAV-h-FZD4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FZD4 (frizzled class receptor 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4; GPCR; hFz4

Description (Vector)

FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Gene ID

8322

Gene Name (Vector)

frizzled class receptor 4

Gene Symbol

FZD4

HGNC ID

HGNC:4042

ORF Size (aa)

1614

ORF Size (bp)

1614 bp

RefSeq ID

NM_012193

RefSeq Synonyms

NM_012193, BC114622, BC114527,

Species

human

UniGene ID

Hs.591968

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.