human FMO5 shRNA silencing AAV

Name
AAV-h-FMO5-shRNA

Cat No
shAAV-209184

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FMO5.

shAAV-209184

AAV-h-FMO5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FMO5 (flavin containing monooxygenase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Gene ID

2330

Gene Name (Vector)

flavin containing monooxygenase 5

Gene Symbol

FMO5

HGNC ID

HGNC:3773

ORF Size (aa)

858

ORF Size (bp)

858 bp

RefSeq ID

NM_001461

RefSeq Synonyms

NM_001461, NM_001144830, NM_001144829, BC035687,

Species

human

UniGene ID

Hs.642706

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.