human FHL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FHL2.
shAAV-209011
AAV-h-FHL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FHL2 (four and a half LIM domains 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AAG11; aging-associated gene 11; down-regulated in rhabdomyosarcoma LIM protein; DRAL; FHL-2; four and a half LIM domains protein 2; LIM domain protein DRAL; skeletal muscle LIM-protein 3; SLIM3; SLIM-3
Description (eCommerce)
FHL2 is a member of the four-and-a-half-LIM-domain protein family which consists of FHL1, FHL2, FHL3, FHL4, and ACT. The LIM domain is a cysteine-rich motif that mediates protein-protein interactions. FHL2 has been shown to function as a transcriptional cofactor and through its LIM domains, interact with a variety of factors which include the androgen receptor, CREB, AP-1, Runx3, SRF, FOXO1, BRCA1 and the HPV-16 E7 oncoprotein. FHL2 has been demonstrated to play an important role in heart and bone development and may influence cancer cell growth.
Description (Vector)
FHL2 encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
2274
Gene Name (eCommerce)
four and a half LIM domains 2
Gene Name (Vector)
four and a half LIM domains 2
Gene Symbol
FHL2
HGNC ID
HGNC:3703
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
840
ORF Size (bp)
840 bp
Protein Name (eCommerce)
Four and a half LIM domains protein 2
RefSeq ID
NM_001450
RefSeq Synonyms
NM_201557, NM_201555, NM_001450, NM_001318899, NM_001318898, NM_001318897, NM_001318896, NM_001318895, NM_001318894, NM_001039492, BC093049, BC014397, BC012742,
Research Areas
Apoptosis,Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,Hypoxia,Metabolism/Metabolic Process,Nuclear Receptor Coactivators,RANKL-RANK Signaling,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
FHL2 is a member of the four-and-a-half-LIM-domain protein family which consists of FHL1, FHL2, FHL3, FHL4, and ACT. The LIM domain is a cysteine-rich motif that mediates protein-protein interactions. FHL2 has been shown to function as a transcriptional cofactor and through its LIM domains, interact with a variety of factors which include the androgen receptor, CREB, AP-1, Runx3, SRF, FOXO1, BRCA1 and the HPV-16 E7 oncoprotein. FHL2 has been demonstrated to play an important role in heart and bone development and may influence cancer cell growth.
UniGene ID
Hs.443687
UniProt ID (eCommerce)
Q14192
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.