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human FGL1 shRNA silencing AAV

Name 
AAV-h-FGL1-shRNA
Cat No 
shAAV-209002
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FGL1.

shAAV-209002
AAV-h-FGL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FGL1 (fibrinogen like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
fibrinogen-like protein 1; hepassocin; hepatocellular carcinoma-related sequence; hepatocyte-derived fibrinogen-related protein 1; HFREP1; HFREP-1; HP-041; LFIRE1; LFIRE-1; liver fibrinogen-related protein 1
Description (eCommerce)
Hepassocin, also known as Fibrinogen-like 1 (FGL1), is a member of the fibrinogen family whose members share a fibrinogen domain at their C-termini. However, it lacks the platelet-binding site, cross-linking region and thrombin-sensitive site which are necessary for fibrin clot formation. Hepassocin/FGL1 is secreted by hepatocytes and may play a role in the development of hepatocellular carcinomas. Hepassocin/FGL1 is an immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 [taken from NCBI Entrez Gene (Gene ID: 2267)].
Description (Vector)
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
Gene ID
2267
Gene Name (eCommerce)
fibrinogen like 1
Gene Name (Vector)
fibrinogen like 1
Gene Symbol
FGL1
HGNC ID
HGNC:3695
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
939
ORF Size (bp)
939 bp
Protein Name (eCommerce)
Fibrinogen-like protein 1
RefSeq ID
NM_004467
RefSeq Synonyms
NM_201553, NM_201552, NM_147203, NM_004467, BC007047,
Research Areas
Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Hepassocin, also known as Fibrinogen-like 1 (FGL1), is a member of the fibrinogen family whose members share a fibrinogen domain at their C-termini. However, it lacks the platelet-binding site, cross-linking region and thrombin-sensitive site which are necessary for fibrin clot formation. Hepassocin/FGL1 is secreted by hepatocytes and may play a role in the development of hepatocellular carcinomas. Hepassocin/FGL1 is an immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 [taken from NCBI Entrez Gene (Gene ID: 2267)].
UniGene ID
Hs.491143
UniProt ID (eCommerce)
Q08830

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.