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human FANCI shRNA silencing AAV

Name 
AAV-h-FANCI-shRNA
Cat No 
shAAV-208704
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FANCI.

shAAV-208704
AAV-h-FANCI-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FANCI (Fanconi anemia complementation group I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Fanconi anemia complementation group I; Fanconi anemia group I protein; KIAA1794; Protein FACI
Description (eCommerce)
FANCI is also known as Fanconi anemia group I protein. FANCI has been identified as the gene underlying Fanconi anemia (FA) complementation group I, an autosomal recessive disorder characterized by a predisposition to malignancies, pancytopenia, and a diverse assortment of congenital malformations. FANCI has been demonstrated to function in the repair of DNA double-stranded breaks and the maintenance of chromosomal stability.
Description (Vector)
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
Gene ID
55215
Gene Name (eCommerce)
FA complementation group I
Gene Name (Vector)
Fanconi anemia complementation group I
Gene Symbol
FANCI
HGNC ID
HGNC:25568
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3987
ORF Size (bp)
3987 bp
Protein Name (eCommerce)
Fanconi anemia group I protein
RefSeq ID
NM_018193
RefSeq Synonyms
NM_018193, NM_001113378, BC166621, BC144483, BC140769,
Research Areas
Cancer,Cell Cycle,DNA Damage/Repair,Fanconi anemia
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
FANCI is also known as Fanconi anemia group I protein. FANCI has been identified as the gene underlying Fanconi anemia (FA) complementation group I, an autosomal recessive disorder characterized by a predisposition to malignancies, pancytopenia, and a diverse assortment of congenital malformations. FANCI has been demonstrated to function in the repair of DNA double-stranded breaks and the maintenance of chromosomal stability.
UniGene ID
Hs.513126
UniProt ID (eCommerce)
Q9NVI1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.