human F5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human F5.
shAAV-208232
AAV-h-F5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human F5 (coagulation factor V). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FVL; PCCF; RPRGL1; THPH2
Description (Vector)
F5 encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
Gene ID
2153
Gene Name (Vector)
coagulation factor V
Gene Symbol
F5
HGNC ID
HGNC:3542
ORF Size (aa)
6675
ORF Size (bp)
6675 bp
RefSeq ID
NM_000130
RefSeq Synonyms
NM_000130, BC113357, BC111929, BC111588, BC111461,
Species
human
UniGene ID
Hs.30054
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.