human F2 shRNA silencing AAV

Name
AAV-h-F2-shRNA

Cat No
shAAV-208221

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human F2.

shAAV-208221

AAV-h-F2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human F2 (coagulation factor II, thrombin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PT; RPRGL2; THPH1

Description (Vector)

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Gene ID

2147

Gene Name (Vector)

coagulation factor II, thrombin

Gene Symbol

HGNC ID

HGNC:3535

ORF Size (aa)

1869

ORF Size (bp)

1869 bp

RefSeq ID

NM_000506

RefSeq Synonyms

NM_001311257, NM_000506, BC051332,

Species

human

UniGene ID

Hs.655207

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.