human ESRRA shRNA silencing AAV

Name
AAV-h-ESRRA-shRNA

Cat No
shAAV-208121

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ESRRA.

shAAV-208121

AAV-h-ESRRA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ESRRA (estrogen related receptor alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ERR1; ERRa; ERRalpha; ESRL1; NR3B1

Description (Vector)

ESRRA is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.

Gene ID

2101

Gene Name (Vector)

estrogen related receptor alpha

Gene Symbol

ESRRA

HGNC ID

HGNC:3471

ORF Size (aa)

1272

ORF Size (bp)

1272 bp

RefSeq ID

NM_004451

RefSeq Synonyms

NM_004451, NM_001282451, NM_001282450, BC093722, BC093720, BC092470, BC063795,

Species

human

UniGene ID

Hs.110849

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.