human EPS8L2 shRNA silencing AAV

Name 
AAV-h-EPS8L2-shRNA
Cat No 
shAAV-208028
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EPS8L2.

shAAV-208028
AAV-h-EPS8L2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPS8L2 (EPS8 like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DFNB106; epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-like protein 2; EPS8R2; EPS8-related protein 2
Description (eCommerce)
EPS8L2 (epidermal growth factor receptor kinase substrate 8-like protein 2) bears significant similarity to eps8. Like eps8, EPS8L2 has been shown to interact with SOS-1, a guanine nucleotide exchange factor (GEF), and activate its Rac-GEF activity. EPS8L2 localizes to PDGF-induced F-actin rich ruffles and plays a role in mediating receptor-tyrosine kinase activated actin remodeling.
Description (Vector)
EPS8L2 encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling.
Gene ID
64787
Gene Name (eCommerce)
EPS8 like 2
Gene Name (Vector)
EPS8 like 2
Gene Symbol
EPS8L2
HGNC ID
HGNC:21296
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2148
ORF Size (bp)
2148 bp
Protein Name (eCommerce)
Epidermal growth factor receptor kinase substrate 8-like protein 2
RefSeq ID
NM_022772
RefSeq Synonyms
NM_022772, BC143242, BC101481, BC093878, BC080636,
Research Areas
Cytoskeleton,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
EPS8L2 (epidermal growth factor receptor kinase substrate 8-like protein 2) bears significant similarity to eps8. Like eps8, EPS8L2 has been shown to interact with SOS-1, a guanine nucleotide exchange factor (GEF), and activate its Rac-GEF activity. EPS8L2 localizes to PDGF-induced F-actin rich ruffles and plays a role in mediating receptor-tyrosine kinase activated actin remodeling.
UniGene ID
Hs.55016
UniProt ID (eCommerce)
Q9H6S3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.