human EPHB4 shRNA silencing AAV

Name
AAV-h-EPHB4-shRNA

Cat No
shAAV-207996

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human EPHB4.

shAAV-207996

AAV-h-EPHB4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPHB4 (EPH receptor B4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HTK; MYK1; TYRO11

Description (Vector)

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

Gene ID

2050

Gene Name (Vector)

EPH receptor B4

Gene Symbol

EPHB4

HGNC ID

HGNC:3395

ORF Size (aa)

2964

ORF Size (bp)

2964 bp

RefSeq ID

NM_004444

RefSeq Synonyms

NM_004444, BC052804,

Species

human

UniGene ID

Hs.437008

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.