human EPHA3 shRNA silencing AAV

Name
AAV-h-EPHA3-shRNA

Cat No
shAAV-207980

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human EPHA3.

shAAV-207980

AAV-h-EPHA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPHA3 (EPH receptor A3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EK4; ETK; ETK1; HEK; HEK4; TYRO4

Description (Vector)

EPHA3 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Gene ID

2042

Gene Name (Vector)

EPH receptor A3

Gene Symbol

EPHA3

HGNC ID

HGNC:3387

ORF Size (aa)

2952

ORF Size (bp)

2952 bp

RefSeq ID

NM_005233

RefSeq Synonyms

NM_182644, NM_005233, BC063282,

Species

human

UniGene ID

Hs.123642

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.