human ELA1 shRNA silencing AAV

Name
AAV-h-ELA1-shRNA

Cat No
shAAV-207813

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CELA1.

shAAV-207813

AAV-h-ELA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CELA1 (chymotrypsin like elastase family member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ELA1

Description (Vector)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B.

Gene ID

1990

Gene Name (Vector)

chymotrypsin like elastase family member 1

Gene Symbol

CELA1

HGNC ID

HGNC:3308

ORF Size (aa)

777

ORF Size (bp)

777 bp

RefSeq ID

NM_001971

RefSeq Synonyms

NM_001971, BC075091, BC069454,

Species

human

UniGene ID

Hs.348395

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.