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human EIF3L shRNA silencing AAV

Name 
AAV-h-EIF3L-shRNA
Cat No 
shAAV-207760
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EIF3L.

shAAV-207760
AAV-h-EIF3L-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EIF3L (eukaryotic translation initiation factor 3 subunit L). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
eIEF associated protein HSPC021; EIF3EIP; eIF3l; EIF3S11; EIF3S6IP; eukaryotic translation initiation factor 3 subunit 6-interacting protein; eukaryotic translation initiation factor 3 subunit E-interacting protein; eukaryotic translation initiation factor 3 subunit L; HSPC021; HSPC025; MSTP005
Description (eCommerce)
Eukaryotic translation initiation factor 3 subunit L (EIF3L) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y262].
Gene ID
51386
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit L
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit L
Gene Symbol
EIF3L
HGNC ID
HGNC:18138
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1695
ORF Size (bp)
1695 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit L
RefSeq ID
NM_016091
RefSeq Synonyms
NM_016091, NM_001242923, BC029265, BC007510, BC001101,
Research Areas
Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Eukaryotic translation initiation factor 3 subunit L (EIF3L) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y262].
UniGene ID
Hs.446852
UniProt ID (eCommerce)
Q9Y262

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.