human EIF3G shRNA silencing AAV

Name 
AAV-h-EIF3G-shRNA
Cat No 
shAAV-207751
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EIF3G.

shAAV-207751
AAV-h-EIF3G-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EIF3G (eukaryotic translation initiation factor 3 subunit G). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
eIF3 p42; eIF3 p44; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3-delta; eIF3g; EIF3-P42; eIF3-p44; EIF3S4; eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
Description (eCommerce)
Eukaryotic initiation factor 3 subunit G (eIF3G) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3G has been shown to directly interact with AIF (apoptosis inducing factor), a protein that plays a role in caspase-independent apoptosis. AIF is able to inhibit protein synthesis via its interaction with eIF3g.
Gene ID
8666
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit G
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit G
Gene Symbol
EIF3G
HGNC ID
HGNC:3274
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
963
ORF Size (bp)
963 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit G
RefSeq ID
NM_003755
RefSeq Synonyms
NM_003755, BC008469, BC000733,
Research Areas
Gene Expression,Metabolism/Metabolic Process,mRNA Binding,RNA Binding,RNA Transport,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,metabolism,cell_biology
Species
human
Target Sentence
Eukaryotic initiation factor 3 subunit G (eIF3G) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3G has been shown to directly interact with AIF (apoptosis inducing factor), a protein that plays a role in caspase-independent apoptosis. AIF is able to inhibit protein synthesis via its interaction with eIF3g.
UniGene ID
Hs.529059
UniProt ID (eCommerce)
O75821

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.