human EIF2AK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EIF2AK3.
shAAV-207708
AAV-h-EIF2AK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PEK; PERK; WRS
Description (Vector)
EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Gene ID
9451
Gene Name (Vector)
eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol
EIF2AK3
HGNC ID
HGNC:3255
ORF Size (aa)
3348
ORF Size (bp)
3348 bp
RefSeq ID
NM_004836
RefSeq Synonyms
NM_004836, NM_001313915, BC126356, BC126354,
Species
human
UniGene ID
Hs.591589
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.