human EBP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EBP.
shAAV-207519
AAV-h-EBP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EBP (emopamil binding protein (sterol isomerase)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDPX2; CHO2; CPX; CPXD; MEND
Description (Vector)
EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist (3H)emopamil and the photoaffinity label (3H)azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Gene ID
10682
Gene Name (Vector)
emopamil binding protein (sterol isomerase)
Gene Symbol
EBP
HGNC ID
HGNC:3133
ORF Size (aa)
693
ORF Size (bp)
693 bp
RefSeq ID
NM_006579
RefSeq Synonyms
NM_006579, BC046501, BC001572, BC001549,
Species
human
UniGene ID
Hs.30619
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.