human DUSP7 shRNA silencing AAV

Name
AAV-h-DUSP7-shRNA

Cat No
shAAV-207441

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DUSP7.

shAAV-207441

AAV-h-DUSP7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DUSP7 (dual specificity phosphatase 7). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MKPX; PYST2

Description (Vector)

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 (PubMed 19228121)).(supplied by OMIM, Dec 2009)

Gene ID

1849

Gene Name (Vector)

dual specificity phosphatase 7

Gene Symbol

DUSP7

HGNC ID

HGNC:3073

ORF Size (aa)

1107

ORF Size (bp)

1107 bp

RefSeq ID

NM_001947

RefSeq Synonyms

NM_001947, BC104882, BC104880, BC019107,

Species

human

UniGene ID

Hs.591664

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.