human DPM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DPM1.
shAAV-207279
AAV-h-DPM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDGIE; MPDS
Description (Vector)
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
Gene ID
8813
Gene Name (Vector)
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Gene Symbol
DPM1
HGNC ID
HGNC:3005
ORF Size (aa)
783
ORF Size (bp)
783 bp
RefSeq ID
NM_003859
RefSeq Synonyms
NM_003859, NM_001317036, NM_001317035, NM_001317034, BC016322, BC008466, BC007073,
Species
human
UniGene ID
Hs.654951
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.