human DOK7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DOK7.
shAAV-207251
AAV-h-DOK7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DOK7 (docking protein 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C4orf25; CMS10; CMS1B
Description (Vector)
DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
Gene ID
285489
Gene Name (Vector)
docking protein 7
Gene Symbol
DOK7
HGNC ID
HGNC:26594
ORF Size (aa)
1515
ORF Size (bp)
1515 bp
RefSeq ID
NM_173660
RefSeq Synonyms
NM_173660, NM_001301071, NM_001256896, NM_001164673, BC141852, BC131544,
Species
human
UniGene ID
Hs.701584
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.