human DOCK9 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DOCK9.
shAAV-207238
AAV-h-DOCK9-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DOCK9 (dedicator of cytokinesis 9). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cdc42 guanine nucleotide exchange factor zizimin-1; dedicator of cytokinesis protein 9; ZIZ1; ZIZIMIN1; zizimin-1
Description (eCommerce)
Dedicator of cytokinesis protein 2 (DOCK2) is Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. DOCK2 activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK2 may also participate in IL2 transcriptional activation via the activation of RAC2Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92608].
Gene ID
23348
Gene Name (eCommerce)
dedicator of cytokinesis 9
Gene Name (Vector)
dedicator of cytokinesis 9
Gene Symbol
DOCK9
HGNC ID
HGNC:14132
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3765
ORF Size (bp)
3765 bp
Protein Name (eCommerce)
Dedicator of cytokinesis protein 9
RefSeq ID
NM_015296
RefSeq Synonyms
NM_015296, NM_001318849, NM_001130050, NM_001130049, NM_001130048, BC171753, BC146814, BC136274,
Research Areas
Cell Biology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
Dedicator of cytokinesis protein 2 (DOCK2) is Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. DOCK2 activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK2 may also participate in IL2 transcriptional activation via the activation of RAC2Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92608].
UniGene ID
Hs.596105
UniProt ID (eCommerce)
Q9BZ29
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.