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human DNASE2B shRNA silencing AAV

Name 
AAV-h-DNASE2B-shRNA
Cat No 
shAAV-207194
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DNASE2B.

shAAV-207194
AAV-h-DNASE2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DNASE2B (deoxyribonuclease 2 beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DLAD
Description (Vector)
DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
Gene ID
58511
Gene Name (Vector)
deoxyribonuclease 2 beta
Gene Symbol
DNASE2B
HGNC ID
HGNC:28875
ORF Size (aa)
1074
ORF Size (bp)
1074 bp
RefSeq ID
NM_021233
RefSeq Synonyms
NM_058248, NM_021233, BC126138, BC126136,
Species
human
UniGene ID
Hs.129142

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.