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human DNAJC13 shRNA silencing AAV

Name 
AAV-h-DNAJC13-shRNA
Cat No 
shAAV-207150
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DNAJC13.

shAAV-207150
AAV-h-DNAJC13-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; dnaJ homolog subfamily C member 13; PARK21; required for receptor-mediated endocytosis 8; RME8; RME-8
Description (eCommerce)
DnaJ homolog subfamily C member 13 (DNAJC13) is involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). it is also involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75165].
Gene ID
23317
Gene Name (eCommerce)
DnaJ heat shock protein family (Hsp40) member C13
Gene Name (Vector)
DnaJ heat shock protein family (Hsp40) member C13
Gene Symbol
DNAJC13
HGNC ID
HGNC:30343
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6732
ORF Size (bp)
6732 bp
Protein Name (eCommerce)
DnaJ homolog subfamily C member 13
RefSeq ID
NM_015268
RefSeq Synonyms
NM_015268, NM_001329126, BC151246,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
DnaJ homolog subfamily C member 13 (DNAJC13) is involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). it is also involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75165].
UniGene ID
Hs.12707
UniProt ID (eCommerce)
O75165

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.