human DMGDH shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DMGDH.
shAAV-207089
AAV-h-DMGDH-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DMGDH (dimethylglycine dehydrogenase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DMGDHD; ME2GLYDH
Description (Vector)
DMGDH encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
Gene ID
29958
Gene Name (Vector)
dimethylglycine dehydrogenase
Gene Symbol
DMGDH
HGNC ID
HGNC:24475
ORF Size (aa)
2598
ORF Size (bp)
2598 bp
RefSeq ID
NM_013391
RefSeq Synonyms
NM_013391, BC172462, BC156312,
Species
human
UniGene ID
Hs.655653
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.