human DICER1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DICER1.
shAAV-206990
AAV-h-DICER1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DICER1 (dicer 1, ribonuclease III). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DCR1; Dicer; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Dicer1, Dcr-1 homolog; Dicer1e; endoribonuclease Dicer; helicase MOI; helicase with RNAse motif; HERNA; K12H4.8-LIKE; MNG1; RMSE2
Description (eCommerce)
Dicer is one of three human RNase III enzymes (Drosha, Dicer, and Argonaute) that plays a diverse role in the processing and maturation of RNA. Dicer is involved in processing pre-cursor mRNAs into both microRNAs (miRNAs) and short interfering RNAs (siRNAs) for the gene-silencing pathways of RNA interference (RNAi). Dicer interacts with Argonaute 2 (Ago2) and TRBP (TAR RNA-binding protein).
Description (Vector)
DICER1 encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Gene ID
23405
Gene Name (eCommerce)
dicer 1, ribonuclease III
Gene Name (Vector)
dicer 1, ribonuclease III
Gene Symbol
DICER1
HGNC ID
HGNC:17098
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5769
ORF Size (bp)
5769 bp
Protein Name (eCommerce)
Endoribonuclease Dicer
RefSeq ID
NM_030621
RefSeq Synonyms
NM_177438, NM_030621, NM_001291628, NM_001271282, NM_001195573, BC150287,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Gene Expression,Helicase Activity,Host-Virus Interactions,MicroRNAs in Cancer,mRNA Processing,Neurobiology,Neurodevelopment,Response to Virus,RNA Binding,RNA Processing
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
Dicer is one of three human RNase III enzymes (Drosha, Dicer, and Argonaute) that plays a diverse role in the processing and maturation of RNA. Dicer is involved in processing pre-cursor mRNAs into both microRNAs (miRNAs) and short interfering RNAs (siRNAs) for the gene-silencing pathways of RNA interference (RNAi). Dicer interacts with Argonaute 2 (Ago2) and TRBP (TAR RNA-binding protein).
UniGene ID
Hs.87889
UniProt ID (eCommerce)
Q9UPY3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.