human DEFB1 shRNA silencing AAV

Name
AAV-h-DEFB1-shRNA

Cat No
shAAV-206806

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DEFB1.

shAAV-206806

AAV-h-DEFB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DEFB1 (defensin beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BD1; DEFB-1; DEFB101; HBD1

Description (Vector)

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.

Gene ID

1672

Gene Name (Vector)

defensin beta 1

Gene Symbol

DEFB1

HGNC ID

HGNC:2766

ORF Size (aa)

207

RefSeq ID

NM_005218

RefSeq Synonyms

NM_005218, BC047677, BC033298,

Species

human

UniGene ID

Hs.32949

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.