human DDX46 shRNA silencing AAV

Name 
AAV-h-DDX46-shRNA
Cat No 
shAAV-206763
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DDX46.

shAAV-206763
AAV-h-DDX46-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DDX46 (DEAD-box helicase 46). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box protein 46; probable ATP-dependent RNA helicase DDX46; Prp5; PRP5 homolog; Prp5-like DEAD-box protein; PRPF5; RNA helicase
Description (eCommerce)
DDX46 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX46 is a component of the 17S U2 snRNP complex and plays and important role in pre-mRNA splicing.
Description (Vector)
DDX46 encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing.
Gene ID
9879
Gene Name (eCommerce)
DEAD-box helicase 46
Gene Name (Vector)
DEAD-box helicase 46
Gene Symbol
DDX46
HGNC ID
HGNC:18681
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3096
ORF Size (bp)
3096 bp
Protein Name (eCommerce)
Probable ATP-dependent RNA helicase DDX46
RefSeq ID
NM_014829
RefSeq Synonyms
NM_014829, NM_001300860, BC012304,
Research Areas
Gene Expression,Helicase Activity,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
DDX46 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX46 is a component of the 17S U2 snRNP complex and plays and important role in pre-mRNA splicing.
UniGene ID
Hs.406549
UniProt ID (eCommerce)
Q7L014

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.