human DDX10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DDX10.
shAAV-206726
AAV-h-DDX10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DDX10 (DEAD-box helicase 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Dbp4; DDX10-NUP98 fusion protein type 2; DEAD (Asp-Glu-Ala-Asp) box polypeptide 10; DEAD box protein 10; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase); HRH-J8; probable ATP-dependent RNA helicase DDX10
Description (eCommerce)
DDX10 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX10 may play a particular role in ribosome assembly. DDX10 has been observed to be involved in a chromosomal translocation and fused with the nucleoporin gene, NUP98, in myeloid malignancies.
Description (Vector)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.
Gene ID
1662
Gene Name (eCommerce)
DEAD-box helicase 10
Gene Name (Vector)
DEAD-box helicase 10
Gene Symbol
DDX10
HGNC ID
HGNC:2735
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2628
ORF Size (bp)
2628 bp
Protein Name (eCommerce)
Probable ATP-dependent RNA helicase DDX10
RefSeq ID
NM_004398
RefSeq Synonyms
NM_004398, BC093656, BC093654, BC091521,
Research Areas
Helicase Activity,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DDX10 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX10 may play a particular role in ribosome assembly. DDX10 has been observed to be involved in a chromosomal translocation and fused with the nucleoporin gene, NUP98, in myeloid malignancies.
UniGene ID
Hs.591931
UniProt ID (eCommerce)
Q13206
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.