human DDAH1 shRNA silencing AAV

Name 
AAV-h-DDAH1-shRNA
Cat No 
shAAV-206691
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DDAH1.

shAAV-206691
AAV-h-DDAH1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DDAH1 (dimethylarginine dimethylaminohydrolase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DDAH; DDAH-1; DDAHI; dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1; epididymis secretory protein Li 16; HEL-S-16; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; NG, NG-dimethylarginine dimethylaminohydrolase
Description (eCommerce)
Dimethylargininase-1 (DDAH1) hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Therefore, DDAH1 has a role in the regulation of nitric oxide generation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O94760].
Description (Vector)
DDAH1 belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.
Gene ID
23576
Gene Name (eCommerce)
dimethylarginine dimethylaminohydrolase 1
Gene Name (Vector)
dimethylarginine dimethylaminohydrolase 1
Gene Symbol
DDAH1
HGNC ID
HGNC:2715
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
858
ORF Size (bp)
858 bp
Protein Name (eCommerce)
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
RefSeq ID
NM_012137
RefSeq Synonyms
NM_012137, NM_001330655, NM_001134445, BC033680,
Research Areas
Angiogenesis,Cardiovascular,Mitochondrion
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology
Species
human
Target Sentence
Dimethylargininase-1 (DDAH1) hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Therefore, DDAH1 has a role in the regulation of nitric oxide generation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O94760].
UniGene ID
Hs.379858
UniProt ID (eCommerce)
O94760

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.