human DCP2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DCP2.
shAAV-206665
AAV-h-DCP2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DCP2 (decapping mRNA 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DCP2 decapping enzyme homolog; hDpc; m7GpppN-mRNA hydrolase; mRNA-decapping enzyme 2; Nucleoside diphosphate-linked moiety X motif 20; nudix (nucleoside diphosphate linked moiety X)-type motif 20; Nudix motif 20; NUDT20
Description (eCommerce)
mRNA-decapping enzyme 2 (Dcp2) is required for both normal mRNA turnover and nonsense-mediated mRNA decay. Dcp2 plays a role in replication-dependent histone mRNA degradation. It removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IU60].
Description (Vector)
DCP2 is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
167227
Gene Name (eCommerce)
decapping mRNA 2
Gene Name (Vector)
decapping mRNA 2
Gene Symbol
DCP2
HGNC ID
HGNC:24452
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1158
ORF Size (bp)
1158 bp
Protein Name (eCommerce)
m7GpppN-mRNA hydrolase
RefSeq ID
NM_152624
RefSeq Synonyms
NM_152624, NM_001242377, BC064593,
Research Areas
Gene Expression,mRNA Binding,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
mRNA-decapping enzyme 2 (Dcp2) is required for both normal mRNA turnover and nonsense-mediated mRNA decay. Dcp2 plays a role in replication-dependent histone mRNA degradation. It removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IU60].
UniGene ID
Hs.443875
UniProt ID (eCommerce)
Q8IU60
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.