human DCC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DCC.
shAAV-206639
AAV-h-DCC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DCC (DCC netrin 1 receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
Description (Vector)
DCC encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Gene ID
1630
Gene Name (Vector)
DCC netrin 1 receptor
Gene Symbol
DCC
HGNC ID
HGNC:2701
ORF Size (aa)
4341
ORF Size (bp)
4341 bp
RefSeq ID
NM_005215
RefSeq Synonyms
NM_005215, BC152808,
Species
human
UniGene ID
Hs.579550
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.